IRS1GenotypeModulatesMetabolic Syndrome Reversion in Response to 2-YearWeight-Loss Diet Intervention The POUNDS LOST trial
نویسندگان
چکیده
RESEARCH DESIGN AND METHODSdTwo variants near IRS1, rs1522813 and rs2943641, were genotyped in 738 overweight/obese adults (age 60 6 9 years; BMI 32.7 6 3.9 kg/m) randomly assigned to one of four weight-loss diets (a deficit of 750 kcal/day of caloric intake from baseline) varying in macronutrient contents for 2 years. We comparedMetS status of high-fat (40% of caloric intake; n = 370) and low-fat (20% caloric intake; n = 368) diet groups differentiated by genotypes (rs1522813 A-allele carriers and noncarriers; rs2943641T-allele carriers and noncarriers).
منابع مشابه
CETP genotype and changes in lipid levels in response to weight-loss diet intervention in the POUNDS LOST and DIRECT randomized trials.
Little is known about whether cholesteryl ester transfer protein (CETP) genetic variation may modify the effect of weight-loss diets varying in fat content on changes in lipid levels. We analyzed the interaction between the CETP variant rs3764261 and dietary interventions on changes in lipid levels among 732 overweight/obese adults from a 2 year randomized weight-loss trial [Preventing Overweig...
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